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KMID : 0378019830260080131
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New Medical Journal
1983 Volume.26 No. 8 p.131 ~ p.134
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The Effect of Adchon^(®) on Capillary Resistance in Diabetes Mellitus
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Abstract
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It is suggested that the vascular complications of diabetes mellitus are due to increased vascular permeability and decreased vascular wall resistance. Adchon® (Adrenochromemonoaminoguanidine-methane-sulfonate) is a derivative of adrenochrome and known to decrease vascular permeability and increase vascular wall resistance. So we evaluated the effect of Adchon® on the vascular resistance with negative pressure methods in diabetic patients. Adchon® ingested orally, 180mg a day, for 4 weeks and coagulation study, platelet count, blood sugar, fundcscopic finding and capillary resistance were checked weekly.
The results as follows:
1. Coagulation study, platelet and blood sugar were not significantly different between both groups before and after Adchone administration.
2. After 4 weeks, capillary resistance checked with negative pressure method improved. in 8 (66. 7%) of 12 Adchone ingested patients but only in 2(18. 1%) of 11 contorl patients.
3. There were no remarkible side reaction after Adchen® ingestion.
We conclude that Adchon is effective in increasing capillary resistance so it would be effective in preventing and treating vascular complications of diabetes mellitus.
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